Current Issue : July - September Volume : 2015 Issue Number : 3 Articles : 6 Articles
Polymers obtained from natural origin has great compliance in pharmaceutical industry and most suitable for use in formulations. Sago is a powdery starch made extracted in the spongy centre or pith, of various tropical palm stems, especially Metroxylon sagu. The present study was aimed to characterize the sago powder for various excipient activities. This excipient was proposed to have binder, disintegrating agent, emulsifying agent and thickening agent activity. Based on the results obtained, this excipient if used in formulations can serve as a biocompatible, cost effective polymer and can also act as nutritional supplement....
The main aim of the present study was to develop diclofenac potassium tablets by wet granulation technique using different concentration of natural binder Aloe barbadensis miller mucilage. Prepared formulations were evaluated for precompressional parameter such as hardness, friability, angle of repose, disintegration test. The formulation prepared with Aloe barbadensis miller mucilage showed disintegration time of 50 min. The result concluded that compression tablet of poorly water soluble drug; diclofenac potassium showed enhanced disintegration, which leads to improved bioavaibility, improved effectiveness and hence better patient compliance by using natural binder like Aloe barbadensis miller mucilage....
The present study was aimed at developing and exploring the use of long circulating biocompatible PEGylated PPI 5.0G dendrimers for delivery of an anti-cancer drug, Imatinib. The PPI 5.0G dendrimers were synthesized and PEGylated using dicyclohexyl carbodimide (DCC). PEGylation was confirmed by IR, NMR. The Imatinib was loaded in PEGylated dendritic system and pH dependent in-vitro drug release was determined. The in-vitro release studies demonstrated suitability of PEGylated PPI 5.0G dendrimer for prolonged delivery of Imatinib. PEGylation is considered to be suitable for amendment of PPI dendrimers for improving drug-loading capacity and stabilizes the system in body. The results suggested that, such PEGylated dendrimeric system is suitable for sustained delivery of imatinib....
The development of drug products for pediatric use often requires age-appropriate\nformulations which can be more complex and may involve a broader range of excipients\nthan adult dosage forms. Excipients established for adult use are not always appropriate for use\nin children because they can affect children differently than adults. Therefore, a comprehensive\nsafety assessment of the excipients in a pediatric formulation is essential before use,\nreferring to existing safety data from adult human and animals as well as safety data from\npediatric use and juvenile toxicity studies, when available. The overall risk assessment\nneeds to consider the safety risk from the excipients and the extent to which the risk from\nthe disease as such will be ameliorated by the drug formulation. Non-clinical safety studies\nin juvenile animals are used to assess for specific toxicities or sensitivities of excipients\nand for establishing safe exposures in pediatric age groups. As for any active ingredient,\nnon-clinical safety studies in juvenile animals should only be performed for excipients if\nimportant for clinical risk assessment and labelling. Pharmaceutical companies should be\ncritical of excessive demands for juvenile animal testing, particularly of excipients when\ncritically needed for significant therapeutic benefit....
The intent of present review article is to highlight the research work carried out by researchers till date on sesbania species. Special emphasis is given on sesbania gum which is a high molecular weight hydrocolloidal natural polysaccharide composed of galactose and mannose units combined through glycosidic linkages which is obtained from the endosperm of the seeds of various species of sesbania such as S. aculeata (S. Bispinosa), S. grandiflora, etc. The structurally and characteristically sesbania gum is very similar to the guar gum (produced by Cyamopsis tetragonolobus). Guar gum and its derivatives are well explored as pharmaceutical excipient in various conventional as well as novel dosage forms and in other industrial applications, as compared with sesbania gum. Relatively, very less literature is available about the use of sesbania gum as a pharmaceutical excipient and it is investigated in a lesser extent as compared with guar gum, which might be due to lack of adequate information on it. In recent years many researchers showed an immense interest in exploring its structural and functional properties. This review article brings to light structural properties, functional properties and application of various species of sesbania gum. Various parts of the sesbania species are found to have excellent applications in pharmaceuticals due to their medicinal and excipient properties as well as it has many other miscellaneous applications in agriculture, food, paper, printing and textile industries, which are briefly discussed in present article. Many researchers have modified basic structure of sesbania gum by various methods to improve its effectiveness and functional properties for its better utilization in pharmaceuticals as well as other industries....
Cellulose is an important pharmaceutical excipient. This study aimed to produce cellulose from the fiber of Luffa cylindrica as an\neffective binder in the formulation of acetaminophen tablets. This study was divided into three phases, namely, (I) preparation of\ncellulose fromLuffa cylindrica, (II) determination of the powder properties of the LC-cellulose, and (III) production and evaluation\nof acetaminophen of the tablets produced using LC-cellulose as binder.The percentage yield of LC-cellulose was 61%. The values\nof the powder properties of LC-cellulose produced show fair and passable flow properties and are within the specifications of a\npowdered pharmaceutical excipient. The mean tablet hardness and disintegration time of the LC-cellulose tablets have a significant\ndifference in the mean tablet hardness and disintegration time of the tablets without binder; thus the cellulose produced improved\nthe suitability of acetaminophen in the dry compression process. However, the tablet properties of the tablets produced using LCcellulose\nas binder do not conformto the specifications of the US pharmacopeia; thus the study of additional methods and excipients\nis recommended....
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